Journal Publications

Biofabrication of Thick Vascularized Neo-Pedicle Flaps for Reconstructive Surgery.
Stephens, C., Spector, J.A., Butcher, J.T.
Translational Medicine. 2019 Sep;211:84-122. doi: 10.1016/j.trsl.2019.05.003. Epub 2019 May 21. Review. PMID: 31170376.

Calpain 9 as a Novel Therapeutic Target in TGFb-Induced Mesenchymal Transition and Fibrosis.
David H. Kim, James D. Beckett, Varun Nagpal, Manuel A. Seman-Senderos, Russell A. Gould, Tyler J. Creamer, Elena Gallo MacFarlane, Yichun Chen, Djahida Bedja, Jonathan T. Butcher, Wayne Mitzner, Rosanne Rouf, Shoji Hata, Daniel S. Warren, Harry C. Dietz.
Science Translational Medicine. 2019 Jul 17;11(501). pii: eaau2814. doi: 10.1126/scitranslmed.aau2814. PMID: 31316008.

Spatial regulation of valve interstitial cell phenotypes within three-dimensional micropatterned hydrogels.
Duan, B., Xu, C., Das, S., Chen, J.M., and Butcher, J.T.
ACS Biomaterials Science and Engineering. 2019 [In press].

Systematic analysis of the smooth muscle wall phenotype of the pharyngeal arch arteries during their reorganization into the great vessels and its association with hemodynamics.
Ryvlin, J.*, Lindsey, S.E.*, and Butcher, J.T.
Anatomical Record. s;302(1):153-162. doi: 10.1002/ar.23942. Epub 2018 Nov 9.
*These authors contributed equally to this work. PMID: 30312026 PMCID: PMC6312499.

ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm.
Gould RA, Aziz H, Woods CE, Seman-Senderos MA, Sparks E, Preuss C, Wünnemann F, Bedja D, Moats CR, McClymont SA, Rose R, Sobreira N, Ling H, MacCarrick G, Kumar AA, Luyckx I, Cannaerts E, Verstraeten A, Björk HM, Lehsau AC, Jaskula-Ranga V, Lauridsen H, Shah AA, Bennett CL, Ellinor PT, Lin H, Isselbacher EM, Lino Cardenas CL, Butcher JT, Hughes GC, Lindsay ME; Baylor-Hopkins Center for Mendelian Genomics; MIBAVA Leducq Consortium, Mertens L, Franco-Cereceda A, Verhagen JMA, Wessels M, Mohamed SA, Eriksson P, Mital S, Van Laer L, Loeys BL, Andelfinger G, McCallion AS, Dietz HC.
Nat Genet. 2019 Jan;51(1):42-50. doi: 10.1038/s41588-018-0265-y. Epub 2018 Nov 19. PMID: 30455415 PMCID: PMC6309588.

Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program.
Yu, J.K., Sarathchandra, P., Chester, A., Yacoub, M., Brand, T., and Butcher, J.T.
Scientific Reports 2018 Oct 23;8(1):15661. doi: 10.1038/s41598-018-33994-8. PMID: 30353076. PMCID: PMC6199254

Cohort-based multiscale analysis of hemodynamic-driven growth and remodeling of the embryonic pharyngeal arch.
Lindsey, S., Butcher, JT*, and Vingon-Clementel, I*.
Development 2018 Oct 17;145(20). pii: dev162578. DOI: 10.1242/dev.162578. PMID: 30333235
*Co-corresponding author. Featured in a Research Spotlight, Cover Article.  *Co-corresponding author. Cover Article with Science Profile.

Mechanotransduction Mechanisms in Mitral Valve Physiology and Disease Pathogenesis
Leah A. Pagnozzi and Jonathan T. Butcher
Front Cardiovasc Med. 2017; 4: 83

Naturally Engineered Maturation of Cardiomyocytes
Scuderi GJ, Butcher J
Front Cell Dev Biol. 2017 May 5;5:50. doi: 10.3389/fcell.2017.00050. eCollection 2017. Review.

Heart Function and Hemodynamics Analysis for Zebrafish Embryos
Yalcin HC, Amindari A, Butcher JT, Althani A, Yacoub M.
Dev Dyn. 2017 Mar 1

Developmental mechanisms of aortic valve malformation and disease.
Wu B, Wang Y, Xiao F, Butcher JT, Yutzey KE, Zhou B.
Annu Rev Physiol. 2017 Feb 10;79:21-41

Optimizing Photo-Encapsulation Viability of Heart Valve Cell Types in 3D Printable Composite Hydrogels.
Kang LH, Armstrong PA, Lee LJ, Duan B, Kang KH, Butcher JT.
Ann Biomed Eng. 2017 Feb;45(2):360-377

Award Winner in the Young Investigator Category, 2017 Society for Biomaterials Annual Meeting and Exposition, Minneapolis, MN, April 0508, 2017: Lymph node stiffness-mimicking hydrogels regulate human B-cell lymphoma growth and cell surface receptor expression in a molecular subtype-specific manner
Apoorva, FNU; Tian, YF; Pierpont, TM; Bassen, DM; Cerchietti, L; Butcher, JT; Weiss, RS; Singh, A
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 105 (7):1833-1844; 10.1002/jbm.a.36031 JUL 2017

JuPOETs: a constrained multiobjective optimization approach to estimate biochemical model ensembles in the Julia programming language.
Bassen DM, Vilkhovoy M, Minot M, Butcher JT, Varner JD.
BMC Syst Biol. 2017 Jan 25;11(1):10.

Matrix stiffening promotes a tumor vasculature phenotype.
Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA.
Proc Natl Acad Sci U S A. 2016 Dec 29. pii: 201613855. doi: 10.1073/pnas.1613855114. [Epub ahead of print], PMID: 28034921

Living Nano-Micro Fibrous Woven Fabric/Hydrogel Composite Scaffolds for Heart Valve Engineering
Shaohua Wu, Bin Duan, Xiaohong Qin, Jonathan T. Butcher
Acta Biomaterialia, Volume 51, 15 March 2017, Pages 89–100

Population Heterogeneity in the Epithelial to Mesenchymal Transition Is Controlled by NFAT and Phosphorylated Sp1.
Gould R, Bassen DM, Chakrabarti A, Varner JD, Butcher JT.
PLoS Comput Biol. 2016 Dec 27;12(12):e1005251. doi: 10.1371/journal.pcbi.1005251. PMID: 28027307

Valve interstitial cell tensional homeostasis directs calcification and extracellular matrix reModeling processes via RhoA signaling.
Farrar, EJ; Pramil, V; Richards, JM; Mosher, CZ; Butcher, JT
BIOMATERIALS, 105 25-37; 10.1016/j.biomaterials.2016.07.034 OCT 2016

Comparative Analysis of Metallic Nanoparticles as Exogenous Soft Tissue Contrast for Live In Vivo Micro-Computed Tomography Imaging of Avian Embryonic Morphogenesis.
Gregg CL, Butcher JT.
Dev Dyn. 2016 Jul 22. doi: 10.1002/dvdy.24433. [Epub ahead of print], PMID: 27447729

Fabrication of Aligned Nanofiber Polymer Yarn Networks for Anisotropic Soft Tissue Scaffolds.
Wu S, Duan B, Liu P, Zhang C, Qin X, Butcher JT.
ACS Appl. Mater. Interfaces, 2016, 8 (26), pp 16950–16960. DOI: 10.1021/acsami.6b05199, Publication Date (Web): June 15, 2016

Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves.
Sung DC, Bowen CJ, Vaidya KA, Zhou J, Chapurin N, Recknagel A, Zhou B, Chen J, Kotlikoff M, Butcher JT.
Arterioscler Thromb Vasc Biol. 2016 Jun 16. pii: ATVBAHA.116.307812. [Epub ahead of print] PMID: 27312222

Porcine aortic valve interstitial cells in three-dimensional culture: comparison of phenotype with aortic smooth muscle cells
Butcher JT, Nerem RM. Journal of Heart Valve Disease

Endothelial-derived oxidative stress drives myofibroblastic activation and calcification of the aortic valve.
Farrar, E.J.; Huntley, G.D., and Butcher, J.T.
PLoS One. 2015 Apr 13;10(4):e0123257

3D printed hydrogel technologies for tissue engineered heart valves.
Hockaday, L., Duan, B., Kang, K., and Butcher, J.
3D Printing and Additive Manufacturing. September 2014, 1(3): 122-136.

The influence of external free energy and homeostasis on growth and shape change.
Buskohl, P., Butcher, J.T., and Jenkins, J.
Journal of the Mechanics and Physics of Solids. 64: 338-350. Volume 64

The living aortic valve: from molecules to function.
Chester, A.H., El-Hamamsy, I., Butcher, J.T.
Glob. Cardiol. Sci. Pract. 2014 Jan 29;2014(1):52-77

Characterization of Multiple Myeloma Clonal Cell Expansion and Stromal Wnt/β-catenin Signaling in Hyaluronic acid based 3D Hydrogel
Narayanan, N.K., Duan, B., Butcher, J.T.,
In Vivo. 2014 Jan-Feb;28(1):67-73.

Valvular endothelial cells inhibit calcification of valvular interstitial cells in mechanically stressed 3D culture.
Richards, J., Eli-Hamamsy, I., Chen, S., Yacoub, M.H., Chester, A.H., and Butcher. J.T.
American Journal of Pathology May;182(5):1922-31.

Multidisciplinary inquiry-based learning using an ex-ovo chicken culture platform: Role of vitamin A on embryonic morphogenesis.
Buskohl, P.R., Gould, R. A., Curran, S., Archer, S., and Butcher, J.T.
The American Biology Teacher. 2012 Nov/Dec. 74(9): 636-643.

Inflammatory cytokines induce endothelial to mesenchymal transformation in valve endothelial cells via Akt/NFkB.
Mahler, G.J., Farrar, E., and Butcher, J.T.
Arteriosclerosis, Thrombosis, and Vascular Biology 2013 Jan;33(1):121-30.

Serotonin potentiates TGFb3 mediated biomechanical remodeling in the avian atrioventricular valve
Buskohl, P., Sun, M., Thompson, R., and Butcher, J.T.
PLoS One. 2012;7(8):e42527.

Isolation and culture of avian embryonic valvular progenitor cells
Mahler, G.J., and Butcher, J.T. Journal of Visualized Experiments 2010. Dec 29;(46) (Video Journal)

Two-photon guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects
Yalcin, H., Shekar, A., Rane, A., Nishimura, N., Shaffer, C., and Butcher, J.T.
American Journal of Physiology – Heart and Circulatory Physiology. Nov; 299(5): H1728-35. 2010.

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodeling: a role for inflammation.
Hjortnaes, J., Butcher, J.T., Figueiredo, J., Riccio, M., Kohler, R., Weissleder, R., and Aikawa, E.
European Heart Journal 31, 1975-1984. 2010.