Biofabrication of Thick Vascularized Neo-Pedicle Flaps for Reconstructive Surgery.
Stephens, C., Spector, J.A., Butcher, J.T.
Translational Medicine. 2019 Sep;211:84-122. doi: 10.1016/j.trsl.2019.05.003. Epub 2019 May 21. Review. PMID: 31170376.


Calpain 9 as a Novel Therapeutic Target in TGFb-Induced Mesenchymal Transition and Fibrosis.
David H. Kim, James D. Beckett, Varun Nagpal, Manuel A. Seman-Senderos, Russell A. Gould, Tyler J. Creamer, Elena Gallo MacFarlane, Yichun Chen, Djahida Bedja, Jonathan T. Butcher, Wayne Mitzner, Rosanne Rouf, Shoji Hata, Daniel S. Warren, Harry C. Dietz.
Science Translational Medicine. 2019 Jul 17;11(501). pii: eaau2814. doi: 10.1126/scitranslmed.aau2814. PMID: 31316008.


Spatial regulation of valve interstitial cell phenotypes within three-dimensional micropatterned hydrogels.
Duan, B., Xu, C., Das, S., Chen, J.M., and Butcher, J.T.
ACS Biomaterials Science and Engineering. 2019 [In press].


Systematic analysis of the smooth muscle wall phenotype of the pharyngeal arch arteries during their reorganization into the great vessels and its association with hemodynamics.
Ryvlin, J.*, Lindsey, S.E.*, and Butcher, J.T.
Anatomical Record. s;302(1):153-162. doi: 10.1002/ar.23942. Epub 2018 Nov 9.
*These authors contributed equally to this work. PMID: 30312026 PMCID: PMC6312499.


ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm.
Gould RA, Aziz H, Woods CE, Seman-Senderos MA, Sparks E, Preuss C, Wünnemann F, Bedja D, Moats CR, McClymont SA, Rose R, Sobreira N, Ling H, MacCarrick G, Kumar AA, Luyckx I, Cannaerts E, Verstraeten A, Björk HM, Lehsau AC, Jaskula-Ranga V, Lauridsen H, Shah AA, Bennett CL, Ellinor PT, Lin H, Isselbacher EM, Lino Cardenas CL, Butcher JT, Hughes GC, Lindsay ME; Baylor-Hopkins Center for Mendelian Genomics; MIBAVA Leducq Consortium, Mertens L, Franco-Cereceda A, Verhagen JMA, Wessels M, Mohamed SA, Eriksson P, Mital S, Van Laer L, Loeys BL, Andelfinger G, McCallion AS, Dietz HC.
Nat Genet. 2019 Jan;51(1):42-50. doi: 10.1038/s41588-018-0265-y. Epub 2018 Nov 19. PMID: 30455415 PMCID: PMC6309588.


Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program.
Yu, J.K., Sarathchandra, P., Chester, A., Yacoub, M., Brand, T., and Butcher, J.T.
Scientific Reports 2018 Oct 23;8(1):15661. doi: 10.1038/s41598-018-33994-8. PMID: 30353076. PMCID: PMC6199254


Cohort-based multiscale analysis of hemodynamic-driven growth and remodeling of the embryonic pharyngeal arch.
Lindsey, S., Butcher, JT*, and Vingon-Clementel, I*.
Development 2018 Oct 17;145(20). pii: dev162578. DOI: 10.1242/dev.162578. PMID: 30333235
*Co-corresponding author. Featured in a Research Spotlight, Cover Article.  *Co-corresponding author. Cover Article with Science Profile.


Butcher JT
Sci Transl Med. 2018 May 9;10(440). pii: eaat5850. doi: 10.1126/scitranslmed.aat5850
Jennifer M. Richards, Jennie A.M.R. Kunitake, Heather B. Hunt, Alexa N. Wnorowski, Debra W. Lin, Adele L.Boskeyc, Eve Donnelly, Lara A. Estroff, Jonathan T. Butcher
Acta Biomaterialia, Volume 71, 15 April 2018, Pages 24-36
Sraeyes Sridhar, Duc H.Pham, Terence W. Gee, Joanna Hua, Jonathan T. Butcher
Current Opinion in Biomedical Engineering, Volume 5, March 2018, Pages 82-89

Mechanotransduction Mechanisms in Mitral Valve Physiology and Disease Pathogenesis
Leah A. Pagnozzi and Jonathan T. Butcher
Front Cardiovasc Med. 2017; 4: 83


Dorota Wojciechowska, Albert Ryszard Liberski, Piotr Wilczek, Jonathan Butcher, Michael Scharfschwerdt, Ziyad Hijazi,  Jarosław Kasprzak,  Philippe Pibarot, Richard Bianco
QScience Connect 2017, 3, 1
Shaohua Wu; Bin Duan; Xiaohong Qin; Jonathan T. Butcher
Acta Biomater. 2017 Jul 18

Naturally Engineered Maturation of Cardiomyocytes
Scuderi GJ, Butcher J
Front Cell Dev Biol. 2017 May 5;5:50. doi: 10.3389/fcell.2017.00050. eCollection 2017. Review.


Heart Function and Hemodynamics Analysis for Zebrafish Embryos
Yalcin HC, Amindari A, Butcher JT, Althani A, Yacoub M.
Dev Dyn. 2017 Mar 1


Wang Y, Wu B, Farrar E, Lui W, Lu P, Zhang D, Alfieri CM, Mao K, Chu M, Yang D, Xu D, Rauchman M, Taylor V, Conway SJ, Yutzey KE, Butcher JT, Zhou B.
Eur Heart J. 2017 Mar 1;38(9):675-686.

Developmental mechanisms of aortic valve malformation and disease.
Wu B, Wang Y, Xiao F, Butcher JT, Yutzey KE, Zhou B.
Annu Rev Physiol. 2017 Feb 10;79:21-41


Optimizing Photo-Encapsulation Viability of Heart Valve Cell Types in 3D Printable Composite Hydrogels.
Kang LH, Armstrong PA, Lee LJ, Duan B, Kang KH, Butcher JT.
Ann Biomed Eng. 2017 Feb;45(2):360-377


JuPOETs: a constrained multiobjective optimization approach to estimate biochemical model ensembles in the Julia programming language.
Bassen DM, Vilkhovoy M, Minot M, Butcher JT, Varner JD.
BMC Syst Biol. 2017 Jan 25;11(1):10.


Matrix stiffening promotes a tumor vasculature phenotype.
Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA.
Proc Natl Acad Sci U S A. 2016 Dec 29. pii: 201613855. doi: 10.1073/pnas.1613855114. [Epub ahead of print], PMID: 28034921


Living Nano-Micro Fibrous Woven Fabric/Hydrogel Composite Scaffolds for Heart Valve Engineering
Shaohua Wu, Bin Duan, Xiaohong Qin, Jonathan T. Butcher
Acta Biomaterialia, Volume 51, 15 March 2017, Pages 89–100


Population Heterogeneity in the Epithelial to Mesenchymal Transition Is Controlled by NFAT and Phosphorylated Sp1.
Gould R, Bassen DM, Chakrabarti A, Varner JD, Butcher JT.
PLoS Comput Biol. 2016 Dec 27;12(12):e1005251. doi: 10.1371/journal.pcbi.1005251. PMID: 28027307


Valve interstitial cell tensional homeostasis directs calcification and extracellular matrix reModeling processes via RhoA signaling.
Farrar, EJ; Pramil, V; Richards, JM; Mosher, CZ; Butcher, JT
BIOMATERIALS, 105 25-37; 10.1016/j.biomaterials.2016.07.034 OCT 2016


Comparative Analysis of Metallic Nanoparticles as Exogenous Soft Tissue Contrast for Live In Vivo Micro-Computed Tomography Imaging of Avian Embryonic Morphogenesis.
Gregg CL, Butcher JT.
Dev Dyn. 2016 Jul 22. doi: 10.1002/dvdy.24433. [Epub ahead of print], PMID: 27447729


Fabrication of Aligned Nanofiber Polymer Yarn Networks for Anisotropic Soft Tissue Scaffolds.
Wu S, Duan B, Liu P, Zhang C, Qin X, Butcher JT.
ACS Appl. Mater. Interfaces, 2016, 8 (26), pp 16950–16960. DOI: 10.1021/acsami.6b05199, Publication Date (Web): June 15, 2016


Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves.
Sung DC, Bowen CJ, Vaidya KA, Zhou J, Chapurin N, Recknagel A, Zhou B, Chen J, Kotlikoff M, Butcher JT.
Arterioscler Thromb Vasc Biol. 2016 Jun 16. pii: ATVBAHA.116.307812. [Epub ahead of print] PMID: 27312222


Duan B, Yin Z, Hockaday Kang L, Magin RL, Butcher JT.
Acta Biomater. 2016 Mar 3. pii: S1742-7061(16)30091-5. doi: 10.1016/j.actbio.2016.03.007. [Epub ahead of print] PMID: 26947381
JM Richards, I El-Hamamsy, S Chen, Z Sarang, P Sarathchandra, MH Yacoub, AH Chester, and JT Butcher. Am J Path
Henning AL, Jiang MX, Yalcin HC, Butcher JT. Developmental Dynamics
Yalcin HC, Shekhar A, McQuinn TC, Butcher JT. Developmental Dynamics
Yalcin HC, Shekhar A, Nishimura N, Rane AA, Schaffer CB, Butcher JT. Am J Physiol Heart Circ Physiol
Yalcin HC, Shekhar A, Rane AA, Butcher JT. Journal of Visualized Experiments
Otani NF, Singh R, Neumann A, Fenton FH, Infanger DW, Butcher JT, Luther S, Gilmour Jr RF. Computing in Cardiology
Butcher JT, Simmons CA, Warnock JN. Journal of Heart Valve Disease
Norris RA, Borg TK, Butcher JT, Markwald RR. Annals of the New York Academy of Sciences
Metzler SA, Pregonero CA, Butcher JT, Burgess SC, Warnock JN. Journal of Heart Valve Disease
Butcher JT, Sedmera D, Guldberg RE, Markwald RR. Developmental Dynamics
Markwald RR, Butcher JT. Nature Clinical Practice – Cardiovascular Medicine
Butcher JT, Nerem RM. Philosophical Transactions of the Royal Society B – Biological Sciences
Butcher JT, Markwald RR. Philophical Transaction of the Royal Society B: Biological Sciences
Butcher JT, Tressel S, Johnson T, Turner D, Sorescu G, Jo H, Nerem RM. Arteriosclerosis, Thrombosis, and Vascular Biology
Butcher JT, Penrod AM, Garcia AJ, Nerem RM. Arteriosclerosis, Thrombosis, and Vascular Biology
Gould RA, Yalcin HC, MacKay JL, Sauls K, Norris R, Kumar S, Butcher JT.
Curr Biol. 2016 Jan 11;26(1):27-37. doi: 10.1016/j.cub.2015.11.033. Epub 2015 Dec 24. PMID: 26725196
Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH; Leducq Mitral Transatlantic Network.
Nat Rev Cardiol. 2015 Dec;12(12):689-710. doi: 10.1038/nrcardio.2015.161. Epub 2015 Oct 20. Review. PMID: 26483167
Lindsey SE, Menon PG, Kowalski WJ, Shekhar A, Yalcin HC, Nishimura N, Schaffer CB, Butcher JT, Pekkan K.
Biomech Model Mechanobiol. 2015 Aug;14(4):735-51. doi: 10.1007/s10237-014-0633-1. Epub 2014 Nov 23. PMID: 25416845
Bowen CJ, Zhou J, Sung DC, Butcher JT.
Dev Biol. 2015 Nov 1;407(1):145-57. doi: 10.1016/j.ydbio.2015.07.012. Epub 2015 Jul 16. PMID: 26188246
Cheung DY, Duan B, Butcher JT.
Expert Opin Biol Ther. 2015;15(8):1155-72. doi: 10.1517/14712598.2015.1051527. Epub 2015 Jun 1. Review. PMID: 26027436
Judge DP, Neamatalla H, Norris RA, Levine RA, Butcher JT, Vignier N, Kang KH, Nguyen Q, Bruneval P, Perier MC, Messas E, Jeunemaitre X, de Vlaming A, Markwald R, Carrier L, Hagège AA.
J Cardiovasc Dev Dis. 2015;2(2):48-65. Epub 2015 Apr 21. PMID: 26819945
Duan B, Hockaday LA, Das S, Xu C, Butcher JT.
Tissue Eng Part C Methods. 2015 Aug;21(8):795-807. doi: 10.1089/ten.TEC.2014.0589. Epub 2015 Apr 13. PMID: 25594437

Endothelial-derived oxidative stress drives myofibroblastic activation and calcification of the aortic valve.
Farrar, E.J.; Huntley, G.D., and Butcher, J.T.
PLoS One. 2015 Apr 13;10(4):e0123257


Gregg CL, Recknagel AK, Butcher JT.
Methods Mol Biol. 2015;1189:47-61. doi: 10.1007/978-1-4939-1164-6_4. PMID: 25245686
Frendl CM, Tucker SM, Khan NA, Esch MB, Kanduru S, Cao TM, García AJ, King MR, Butcher JT.
Biomaterials. 2014 Sep;35(27):7714-23. doi: 10.1016/j.biomaterials.2014.05.075. Epub 2014 Jun 20. PMID: 24952977

3D printed hydrogel technologies for tissue engineered heart valves.
Hockaday, L., Duan, B., Kang, K., and Butcher, J.
3D Printing and Additive Manufacturing. September 2014, 1(3): 122-136.


Lindsey SE, Butcher JT, Yalcin HC.
Front Physiol. 2014 Aug 21;5:318. doi: 10.3389/fphys.2014.00318. eCollection 2014. Review. PMID: 25191277
Mahler GJ, Frendl CM, Cao Q, Butcher JT.
Biotechnol Bioeng. 2014 Nov;111(11):2326-37. doi: 10.1002/bit.25291. Epub 2014 Aug 5. PMID: 24898772

The influence of external free energy and homeostasis on growth and shape change.
Buskohl, P., Butcher, J.T., and Jenkins, J.
Journal of the Mechanics and Physics of Solids. 64: 338-350. Volume 64


The living aortic valve: from molecules to function.
Chester, A.H., El-Hamamsy, I., Butcher, J.T.
Glob. Cardiol. Sci. Pract. 2014 Jan 29;2014(1):52-77


Zhou J, Bowen C, Lu G, Knapp Iii C, Recknagel A, Norris RA, Butcher JT.
Cells Tissues Organs. 2013;198(4):300-10. doi: 10.1159/000356762. Epub 2013 Dec 20.
Gregg CL, Butcher JT.
Birth Defects Res C Embryo Today. 2013 Jun;99(2):106-20. doi: 10.1002/bdrc.21034. Review.
Tarsi GM, Gould RA, Chung JA, Xu AZ, Bozkurt A, Butcher JT.
J Biomech. 2013 Jul 26;46(11):1938-42. doi: 10.1016/j.jbiomech.2013.05.014. Epub 2013 Jun 19.
Duan B, Hockaday LA, Kapetanovic E, Kang KH, Butcher JT.
Acta Biomater. 2013 Aug;9(8):7640-50. doi: 10.1016/j.actbio.2013.04.050. Epub 2013 May 3.
Kang KH, Hockaday LA, Butcher JT.
Biofabrication. 2013 Sep;5(3):035001. doi: 10.1088/1758-5082/5/3/035001. Epub 2013 May 2.
Duan B, Kapetanovic E, Hockaday LA, Butcher JT.
Acta Biomater. 2014 May;10(5):1836-46. doi: 10.1016/j.actbio.2013.12.005.
Gould RA, Aboulmouna LM, Varner JD, Butcher JT.
Wiley Interdiscip Rev Syst Biol Med. 2013 May-Jun;5(3):289-305. doi: 10.1002/wsbm.1217. Epub 2013 Mar 5. Review.

Valvular endothelial cells inhibit calcification of valvular interstitial cells in mechanically stressed 3D culture.
Richards, J., Eli-Hamamsy, I., Chen, S., Yacoub, M.H., Chester, A.H., and Butcher. J.T.
American Journal of Pathology May;182(5):1922-31.


Multidisciplinary inquiry-based learning using an ex-ovo chicken culture platform: Role of vitamin A on embryonic morphogenesis.
Buskohl, P.R., Gould, R. A., Curran, S., Archer, S., and Butcher, J.T.
The American Biology Teacher. 2012 Nov/Dec. 74(9): 636-643.


Inflammatory cytokines induce endothelial to mesenchymal transformation in valve endothelial cells via Akt/NFkB.
Mahler, G.J., Farrar, E., and Butcher, J.T.
Arteriosclerosis, Thrombosis, and Vascular Biology 2013 Jan;33(1):121-30.


Duan B, Hockaday LA, Kang KH, Butcher JT.
Journal of Biomedical Materials Research, Part A. J Biomed Mater Res A. 2013 May;101(5):1255-64
Gould, R., Sinha, R., Aziz, H., Rouf, R., Deitz, H., Judge, D., and Butcher, J.T.
PLoS One. 2012;7(9):e44639.
Hockaday LA, Kang KH, Colangelo NW, Cheung PY, Duan B, Malone E, Wu J, Girardi LN, Bonassar LJ, Lipson H, Chu CC, Butcher JT.
Biofabrication. 2012 Sep;4(3):035005
Buskohl PR, Jenkins JT, Butcher JT. Biomechanics and Modeling in Mechanobiology
Biomech Model Mechanobiol. 2012 Nov;11(8):1205-17.

Serotonin potentiates TGFb3 mediated biomechanical remodeling in the avian atrioventricular valve
Buskohl, P., Sun, M., Thompson, R., and Butcher, J.T.
PLoS One. 2012;7(8):e42527.


Gould RA, Chin K, Santisakultarm TP, Dropkin A, Richards JM, Schaffer CB, Butcher JT. Acta Biomaterialia
Bhardwaj KN, Spitz C, Shekhar A, Yalcin HC, Butcher JT. Annals of Biomedical Engineering
Annals of Biomedical Engineering. 2012 Oct;40(10):2212-27
Waxman AS, Kornreich BG, Gould RA, Moise SN, Butcher JT. Journal of Veterinary Cardiology
Mahler GJ, Butcher JT. Birth Defects Research C Embryo Today
Lindsey SE, Butcher JT. Aswan Heart Center Science and Practice Series. (Dec 2011)
Richards JM, Farrar EJ, Kornreich BG, Moise NS, Butcher JT. Journal of Veterinary Cardiology
Buskohl PR, Gould RA, Butcher JT. Journal of Biomechanics
Mahler GJ, Butcher JT. International Journal of Inflammation
Butcher JT, Mahler GJ, Hockaday LA. Advanced Drug Delivery Review
Gould RA, Butcher JT. Journal of Visualized Experiments (Video Journal)

Isolation and culture of avian embryonic valvular progenitor cells
Mahler, G.J., and Butcher, J.T. Journal of Visualized Experiments 2010. Dec 29;(46) (Video Journal)


Kim JS, Min J, Recknagel AK, Riccio M, Butcher JT. The Anatomical Record

Two-photon guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects
Yalcin, H., Shekar, A., Rane, A., Nishimura, N., Shaffer, C., and Butcher, J.T.
American Journal of Physiology – Heart and Circulatory Physiology. Nov; 299(5): H1728-35. 2010.


Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodeling: a role for inflammation.
Hjortnaes, J., Butcher, J.T., Figueiredo, J., Riccio, M., Kohler, R., Weissleder, R., and Aikawa, E.
European Heart Journal 31, 1975-1984. 2010.