• CFD of aortic valve

  • Human aortic valve

  • Calcific aortic valve leaflet

  • Calcific valve lesion profiles

  • Microinjection into chick embryo

Welcome to the Butcher Lab

Welcome to the Butcher Lab! We identify principals regulating embryonic valvular development and use the findings to motivate regenerative engineering strategies for heart and valve disease.


Our Main Areas of Research

Thrust 1: Mechanical Regulation of Embryonic Valvulogenesis

Valvulogenesis is the process where heart valves originate and morph into mature thin fibrous leaflets.

Thrust 2: Developmental Redux of Adult Valve Disease

Adult valve disease is characterized by acute or chronic deterioration of leaflet tissue matrix resulting in stenosis and/or regurgitation.

Thrust 3: Embryonically Inspired Heart Valve Regenerative Engineering

Our research efforts in this thrust use information gained from studying embryonic development to inspire solutions to valve diseases.

Latest Publications

Duan B, Yin Z, Hockaday Kang L, Magin RL, Butcher JT.
Acta Biomater. 2016 Mar 3. pii: S1742-7061(16)30091-5. doi: 10.1016/j.actbio.2016.03.007. [Epub ahead of print] PMID: 26947381
Gould RA, Yalcin HC, MacKay JL, Sauls K, Norris R, Kumar S, Butcher JT.
Curr Biol. 2016 Jan 11;26(1):27-37. doi: 10.1016/j.cub.2015.11.033. Epub 2015 Dec 24. PMID: 26725196