• Calcified aortic valve leaflet

  • 3D tissue printing of human aortic valves

  • Transforming K-12 education of physics and biology

  • Time course of avian embryonic morphogenesis

  • 3D Calcified aortic valve lesion created in vitro

Welcome to the Butcher Lab

Welcome to the Butcher Lab! We identify principals regulating embryonic valvular development and use the findings to motivate regenerative engineering strategies for heart and valve disease.

 

Our Main Areas of Research

Thrust 1: Biomechanical Regulation of Valvulogenesis

Heart valves initiate as specific regions of endocardium within the atrioventricular canal and outflow tract of the heart tube that undergo an endocardial to mesenchymal transformation (EMT), formi

Thrust 2: Endothelial-Interstitial Cell Interactions in Valve Homeostasis and Disease

The only treatment for heart valve disease is prosthetic valve replacement.

Thrust 3: Heart Valve Regeneration and Tissue Engineering

The prosthetic valves available to treat heart valve disease are poorly suited for younger and more active patients.

Latest Publications

Duan B, Yin Z, Hockaday Kang L, Magin RL, Butcher JT.
Acta Biomater. 2016 Mar 3. pii: S1742-7061(16)30091-5. doi: 10.1016/j.actbio.2016.03.007. [Epub ahead of print] PMID: 26947381
Gould RA, Yalcin HC, MacKay JL, Sauls K, Norris R, Kumar S, Butcher JT.
Curr Biol. 2016 Jan 11;26(1):27-37. doi: 10.1016/j.cub.2015.11.033. Epub 2015 Dec 24. PMID: 26725196