Welcome to the Butcher Lab! We identify principals regulating embryonic valvular development and use the findings to motivate regenerative engineering strategies for heart and valve disease.
Welcome to the Butcher Lab
Our Main Areas of Research
Thrust 1: Biomechanical Regulation of Valvulogenesis
Heart valves initiate as specific regions of endocardium within the atrioventricular canal and outflow tract of the heart tube that undergo an endocardial to mesenchymal transformation (EMT), formi
Thrust 2: Endothelial-Interstitial Cell Interactions in Valve Homeostasis and Disease
The only treatment for heart valve disease is prosthetic valve replacement.
Thrust 3: Heart Valve Regeneration and Tissue Engineering
The prosthetic valves available to treat heart valve disease are poorly suited for younger and more active patients.
Recent News
01/25/2019
Latest Publications
Method for Specifying and Fabricating and Object, Associated Apparatus, and Applications
Patent No. 10,048,668 B2, Awarded: Aug 14, 2018
Butcher JT
Sci Transl Med. 2018 May 9;10(440). pii: eaat5850. doi: 10.1126/scitranslmed.aat5850