Developmental Redux of Adult Valve Disease

Matrix stiffening promotes a tumor vasculature phenotype.
Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA.
Proc Natl Acad Sci U S A. 2016 Dec 29. pii: 201613855. doi: 10.1073/pnas.1613855114. [Epub ahead of print], PMID: 28034921 

Valve interstitial cell tensional homeostasis directs calcification and extracellular matrix reModeling processes via RhoA signaling.
Farrar, EJ; Pramil, V; Richards, JM; Mosher, CZ; Butcher, JT
BIOMATERIALS, 105 25-37; 10.1016/j.biomaterials.2016.07.034 OCT 2016

Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves.
Sung DC, Bowen CJ, Vaidya KA, Zhou J, Chapurin N, Recknagel A, Zhou B, Chen J, Kotlikoff M, Butcher JT.
Arterioscler Thromb Vasc Biol. 2016 Jun 16. pii: ATVBAHA.116.307812. [Epub ahead of print] PMID: 27312222

Duan B, Yin Z, Hockaday Kang L, Magin RL, Butcher JT.
Acta Biomater. 2016 Mar 3. pii: S1742-7061(16)30091-5. doi: 10.1016/j.actbio.2016.03.007. [Epub ahead of print] PMID: 26947381
Judge DP, Neamatalla H, Norris RA, Levine RA, Butcher JT, Vignier N, Kang KH, Nguyen Q, Bruneval P, Perier MC, Messas E, Jeunemaitre X, de Vlaming A, Markwald R, Carrier L, Hagège AA.
J Cardiovasc Dev Dis. 2015;2(2):48-65. Epub 2015 Apr 21. PMID: 26819945
Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH; Leducq Mitral Transatlantic Network.
Nat Rev Cardiol. 2015 Dec;12(12):689-710. doi: 10.1038/nrcardio.2015.161. Epub 2015 Oct 20. Review. PMID: 26483167
Mahler GJ, Frendl CM, Cao Q, Butcher JT.
Biotechnol Bioeng. 2014 Nov;111(11):2326-37. doi: 10.1002/bit.25291. Epub 2014 Aug 5. PMID: 24898772
Zhou J, Bowen C, Lu G, Knapp Iii C, Recknagel A, Norris RA, Butcher JT.
Cells Tissues Organs. 2013;198(4):300-10. doi: 10.1159/000356762. Epub 2013 Dec 20.
JM Richards, I El-Hamamsy, S Chen, Z Sarang, P Sarathchandra, MH Yacoub, AH Chester, and JT Butcher. Am J Path

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